Patient Information l Common Questions l Important Safety Information
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Talking to Your Doctor

Talking to your doctor is an important part of your treatment. Ask questions. Learn as much as you can about REVATIO. This will help you get the most from your treatment.

Doctor Discussion Guide

Remember to tell your doctor:

  • How you feel and if you have had any problems or improvements
  • All medicines that you take, including over-the-counter medicines or herbal or nutritional medicines
  • Any medical problems in your family
  • Any side effects you may have had
  • Whether you become pregnant or plan to become pregnant

Tell your doctor if you have or ever had:

  • Heart problems such as heart attack, stroke, irregular heartbeat, or chest pain (angina)
  • Problems with high or low blood pressure or blood circulation
  • An eye problem called retinitis pigmentosa
  • Severe liver or kidney disease
  • Any disease or problem with the shape of the penis
  • Any blood problems, such as sickle cell anemia or cancer of blood cells or bone marrow
  • A stomach ulcer or any bleeding problem

Remember to Ask Your Doctor About

Below are questions you may want to ask your doctor. Review them first, and think about other related topics you may also want to discuss.

  1. Should I change my diet, exercise routine, or lifestyle?
  2. How often should I visit or speak to my doctor?
  3. What are my treatment options? Is REVATIO right for me?
  4. How do I take REVATIO?
  5. What can I expect if I take REVATIO as prescribed?
  6. What are the possible side effects of REVATIO?
  7. If I have side effects while taking REVATIO, what should I do?
Next Section: Living With PAH

Important Safety Information

REVATIO is prescribed to treat pulmonary arterial hypertension (WHO Group I) to improve exercise ability. REVATIO has not been studied in patients taking bosentan.

If you take any medicines that contain nitrates (like nitroglycerin for chest pain) — daily or just once in a while — you should NOT take REVATIO.

REVATIO is not recommended for patients taking ritonavir or antifungal medicines, such as ketoconazole and itraconazole. If you are taking REVATIO with bosentan or medicines like barbiturates, carbamazepine, phenytoin, efavirenz, nevirapine, rifampin or rifabutin, your doctor may adjust your dose. Also, tell your doctor if you are taking alpha-blockers for prostate or blood pressure problems.

If you have ever had blockage of veins in your lungs, which is called pulmonary veno-occlusive disease, REVATIO is not recommended for you. If you feel dizzy, have chest pain, or discomfort while taking REVATIO, tell a doctor right away. Also, discuss your general health with your doctor, including if you ever had problems with low blood pressure or blood circulation.

Patients who did not take part in the clinical trial were those who have had: a heart attack, stroke, or life-threatening irregular heartbeat within the last 6 months; chest pain; blood pressure greater than 170/110; eye discoloration; or patients on bosentan.

The safety of REVATIO is not known in patients with bleeding problems and those with stomach ulcers. If you have a condition like these, tell your doctor.

Taking vitamin K antagonists (like coumadin or warfarin) with REVATIO may increase risk of nosebleeds. Tell your doctor if you take such medicines.

In rare cases, men who took PDE5 inhibitors for erectile dysfunction had a sudden decrease or loss of sight in one or both eyes. It is not possible to know if these cases are related directly to these medicines or something else. If you take a PDE5 inhibitor, including REVATIO, and have a sudden decrease or loss of vision, call your doctor right away.

Although rare, erections that last for more than four hours may occur with all drugs in this class. Call a doctor right away if this happens to you. Erections that last more than six hours may lead to long-term loss of potency.

The most common side effects of REVATIO are nosebleeds, headache, upset stomach, flushing, and trouble sleeping.

At doses more than the approved 20 milligrams 3 times a day, some side effects increased. These included flushing, loose stools, muscle pain, and visual disturbances.

Please See Full Prescribing Information for REVATIO

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Pfizer. ©Copyright 2007 Pfizer Inc. All rights reserved. 		RVU00031. August 2007.

The health information contained herein is provided for educational purposes only and is not intended to replace discussions with a healthcare provider. All decisions regarding patient care must be made with a healthcare provider, considering the unique characteristics of the patient.

This product information is intended only for residents of the United States.